Thorne Research

Deproloft-HF is a multi-faceted formula designed to safely enhance mood and cognition.* It combines several known mood-enhancing nutrients and botanicals, such as L-tyrosine and 5-HTP, with other key ingredients, including Rhodiola, Eleutherococcus, and PharmaGABA, to promote healthy neurotransmitter and adrenal function.* Deproloft-HF is "Hypericum free." Hypericum (St. John's wort) is a known inducer of cytochrome p450 3A4 (CYP3A4) and thus can reduce blood levels of medications that are metabolized via this enzyme. Because it does not contain Hypericum, Deproloft-HF is suitable for patients who are taking medications that are metabolized by CYP3A4.* Low serum and red blood cell concentrations of vitamin B12 and folate can have an adverse effect on mood.* Vitamin B12 supports healthy neurological function and red blood cell formation, two factors that can enhance overall mood and stress management.* Deproloft-HF contains 5-MTHF, the active form of folate. Eleuthero (Eleutherococcus senticosus) is a well-known adaptogen and is included in Deproloft-HF to provide general adrenal support.* Gamma aminobutyric acid (GABA), an inhibitory neurotransmitter that balances excessive excitatory responses in the brain, is included to help allay stress and support a calm state of mind.* GABA is provided as the patented, all natural-source PharmaGABA. Deproloft-HF is safe and effective for mood enhancement and a valuable addition to any stress management plan.*