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2 capsules contain:

Vitamin A (from 500IU as Natural Beta Carotene) - 150mcg
Vitamin C (as Ascorbic Acid USP) - 200mg
Vitamin E (from 20IU as d-Alpha Tocopherol Succinate USP) - 13.4mg
Niacin USP - 20mg
Vitamin B6 (as Pyridoxine Hydrochloride USP, Pyridoxal 5'-Phosphate) - 30mg
Vitamin B12 (as Methylcobalamin) - 200mcg
Pantothenic Acid (as d-Calcium Pantothenate USP) - 350mg
Adrenal Concentrate (Bovine) - 220mg
Eleuthero Root Extract (Standardized to contain 0.8% Eleutherosides) - 100mg
Rhodiola rosea Root Extract (Standardized to contain 3% Rosavins) - 100mg
Schisandra Berry Extract - 100mg
Licorice Root Extract 12:1 - 75mg (1)

2 capsules contain:

Vitamin A (from 500IU as Natural Beta Carotene) - 150mcg
Vitamin C (as Ascorbic Acid USP) - 200mg
Vitamin E (from 20IU as d-Alpha Tocopherol Succinate USP) - 13.4mg
Niacin USP - 20mg
Vitamin B6 (as Pyridoxine Hydrochloride USP, Pyridoxal 5'-Phosphate) - 30mg
Vitamin B12 (as Methylcobalamin) - 200mcg
Pantothenic Acid (as d-Calcium Pantothenate USP) - 350mg
Eleuthero Root Extract (Standardized to contain 0.8% Eleutherosides) - 150mg
Rhodiola rosea Root Extract (Standardized to contain 3% Rosavins) - 150mg
Schisandra Berry Extract - 150mg
Ashwagandha Root Extract (Standardized to contain 1.5% Withanolides) - 75mg
Licorice Root Extract 12:1 - 75mg (1)

4 capsules contain:

Vitamin A (from 5,000IU as Natural Beta Carotene) - 1,500mcg
Vitamin C (as Ascorbic Acid USP) - 250mg
Vitamin D (D3 as Cholecalciferol) - 25mcg (1,000IU)
Thiamin (Vitamin B1) (from Thiamine Hydrochloride USP) - 15mg
Riboflavin (Vitamin B2 USP) - 15mg
Vitamin B6 (as Pyridoxine Hydrochloride USP) - 15mg
Folate (from 800mcg as Quatrefolic (6S)-5-Methyltetrahydrofolic acid glucosamine salt) - 1,360mcg DFE
Vitamin B12 (as Methylcobalamin) - 250mcg
Biotin - 50mcg
Pantothenic Acid (as d-Calcium Pantothenate USP) - 15mg
Choline (as Choline Bitartrate) - 15mg
Calcium (as Calcium Citrate USP) - 75mg
Iodine (from Potassium Iodide) - 37mcg
Magnesium (as DiMagnesium Malate) - 75mg
Zinc (as TRAACS Zinc Bisglycinate Chelate) - 5mg
Selenium (as Selenium Glycinate Complex) - 75mcg
Manganese (as TRAACS Manganese Bisglycinate Chelate) - 1mg
Chromium (as O-polynicotinate) - 50mcg
Potassium (as Potassium Citrate USP) - 30mg
N-Acetyl-L-Cysteine USP - 600mg
Acetyl-L-Carnitine Hydrochloride - 500mg
Malic Acid (as DiMagnesium Malate) - 215mg
Alpha Lipoic Acid - 200mg
Mixed Tocopherols - 50mg
Green Tea Leaf Extract (Standardized to contain 45% EGCg (Epigallocatechin gallate)) - 45mg
Broccoli Seed Extract (TrueBroc) (Standardized to contain 13% Glucoraphanin) - 40mg
Inositol NF - 15mg
trans-Resveratrol (from Polygonum cuspidatum (Roots)) - 10mg (2)

Alpha Lipoic Acid Alpha lipoic acid (ALA) is a nutrient required for cellular metabolism, specifically the breakdown of carbohydrates and fatty acids. ALA has been shown to support healthy blood sugar balance by activating an enzyme called adenosine mono-phosphate kinase (AMPK), a major regulator of cellular energy. AMPK coordinates both long-term and short-term metabolic changes, leading to an improvement in energy production and a reduction of energy storage. AMPK activates cellular metabolism by improving insulin sensitivity, downregulating genes involved in fat storage and activating genes involved with burning fat. A study using a dose of 600 mg/day of ALA over three months demonstrated that ALA helps support healthy lipid levels while improving oxidative stress (reducing free radical damage) by 38%. An additional study examining the effects of ALA on 74 subjects found that within the four-week, placebo-controlled trial, administration of 600 mg of ALA per day significantly enhanced glucose transport and utilization. ALA is also a potent antioxidant. It scavenges free radicals while aiding in the regeneration of the body’s antioxidants including vitamin C, vitamin E and glutathione. Through its antioxidant-boosting mechanisms, ALA helps maintain healthy blood vessel and circulatory health. Cinnulin® (Cinnamon Bark Extract) Numerous studies have demonstrated that cinnamon has a beneficial effect on maintaining healthy blood sugar levels. Cinnamon acts by inhibiting several enzymes that play a role in insulin resistance leading to an increase in insulin sensitivity. Diaxinol contains Cinnulin®, which is made using a patented process that extracts the water-soluble components of cinnamon into a potent 20:1 extract (500 mg of Cinnulin® is equivalent to approximately 10 g of whole cinnamon powder). Cinnulin® is standardized to contain doubly-linked polyphenol type A polymers, the bioactive component which has been shown to be effective in clinical trials. In a study examining the effects of Cinnulin®, 24 men and women were given 250 mg of Cinnulin®, or placebo, twice per day. Cinnulin® helped to maintain healthy blood sugar levels in 83% of subjects in the treatment group, compared to 33% in the placebo group. Cinnulin® has also been shown to support healthy body composition by increasing lean body mass while reducing body fat. An additional study examined the effects of 6 g of cinnamon on glucose levels in subjects consuming 50 g of carbohydrates (instant farina cereal). The researchers found that the addition of cinnamon to cereal helped to improve glucose response measurements during the 15, 30, 45 and 60 minutes following the carbohydrate challenge. Chromium Chromium is a critical piece in the molecule glucose tolerance factor (GTF), a complex shown to be crucial for the uptake of glucose into the cells. Studies using 1,000 mcg/day of chromium have demonstrated that chromium helps maintain healthy blood sugar balance, insulin sensitivity and blood lipids. In a study examining the effects of nutrients on blood sugar and lipid regulation, 43 patients were given 600 mcg of chromium along with 2 mg of biotin per day, or placebo. After four weeks, the combination of chromium and biotin was found to have a significant effect on supporting healthy blood sugar balance, while helping to maintain healthy triglyceride and high-density lipoprotein (HDL) cholesterol levels in the treatment group. Biotin Biotin is a B vitamin that plays a major role in energy production by acting as a coenzyme for several carboxylase enzymes involved in the metabolism of fatty acids and amino acids. Biotin also plays numerous roles in maintaining healthy blood sugar balance such as, stimulating glucose-induced insulin secretion, enhancing insulin sensitivity and accelerating glucose metabolism in the liver and pancreas. Biotin also activates glucokinase, a critical enzyme involved in glucose utilization. Additional research has found that biotin supplementation increases the number of insulin secreting beta cells in the pancreas. Vanadyl Sulfate Vanadyl sulfate (VS) is the stable, inorganic form of vanadium, a mineral shown to mimic the action of insulin. VS plays a major role in promoting healthy glucose uptake by stimulating Akt. This causes subsequent activation of GLUT4, the insulin regulated glucose transporter. In a three-week study, VS given at 100 mg/day significantly improved insulin sensitivity. VS was also shown to decrease glucose production by about 20%. An additional study using 100 mg per day of VS for three weeks also demonstrated an improvement in insulin sensitivity while helping to maintain healthy glucose levels. (2)

Chromium Chromium enhances insulin control, promotes healthy glucose metabolism, and supports appetite control. Chromium deficiency impairs the body’s ability to efficiently use glucose to meet its energy needs and raises insulin requirements. Experts suggest that this role makes chromium supplements essential to support insulin function and promote blood sugar balance. In some studies, supplementing chromium at 150 to 1,000 mcg/day has been shown to support healthy HDL, LDL and triglyceride levels. (1)

DHEA DHEA functions as the counterpart to the stress hormone cortisol. Maintaining healthy DHEA levels is crucial for balancing the catabolic effects of cortisol. (1)

Each Gelcap Contains: Calories 10 Calories from Fat 10 Total Fat 1.5 g EPA (Eicosapentaenoic Acid) (from Fish Oil) 450 mg. DHA (Docosahexaenoic Acid) (from Fish Oil) 180 mg. Coenzyme Q10 30 mg. Other Ingredients: Gelatin (bovine), Purified Water and Glycerin (vegetable source) gelcap, Vitamin E (mixed tocopherols). Contains ingredient derived from fish (fish oil = pollock). (1)

Eight Capsules Contain: Vitamin A (12,500 IU from Beta Carotene and 2,500 IU as Palmitate) 15,000 IU. Vitamin C (as Ascorbic Acid) 850 mg. Vitamin D (as Vitamin D3) 1,600 IU. Vitamin E (as d-Alpha Tocopheryl) 400 IU. Vitamin K (as Vitamin K1) 100 mcg. Thiamin (as Thiamin HCl) 40 mg. Riboflavin (as Riboflavin 5'-Phosphate Sodium) 11 mg. Niacin (130 mg as Niacinamide and 30 mg as Niacin) 160 mg. Vitamin B6 (as Pyridoxal 5'-Phosphate) 16.9 mg. Folate (500 mcg as Calcium Folinate and 500 mcg as L-5-Methyltetrahydrofolate from L-5-Methyltetrahydrofolic Acid, Glucosamine Salt ) 1 mg. Vitamin B12 (225 mcg as Adenosylcobalamin and 225 mcg as Methylcobalamin) 450 mcg. Biotin 400 mcg. Pantothenic Acid (as Calcium Pantothenate) 413 mg. Calcium (150 mg as Calcium Citrate and 150 mg as Calcium Malate) 300 mg. Magnesium (142.5 mg as Magnesium Citrate and 142.5 mg as Magnesium Malate) 285 mg. Zinc (as Zinc Picolinate) 30 mg. Selenium (as L-Selenomethionine) 200 mcg. Copper (as Copper Picolinate) 1.5 mg. Manganese (as Manganese Picolinate) 6 mg. Chromium (as TRAACS® Chromium Nicotinate Glycinate Chelate)* 200 mcg. Molybdenum (as Molybdenum Picolinate) 100 mcg. Potassium (45 mg as Potassium Citrate and 45 mg as Potassium Malate) 90 mg. Saw Palmetto extract (fruit) (Serenoa repens)** 160 mg. Choline Citrate 100 mg. Glycine 100 mg. L-Alanine 100 mg. L-Glutamic Acid 100 mg. Hawthorn extract (flowering tops) (Crataegus laevigata) 50 mg. Boron (as Boron Picolinate) 3 mg. Vanadium (as Vanadium Picolinate) 100 mcg. Lutein (from Aztec Marigold extract (flower) (Tagetes erecta)) 192 mcg. Other Ingredients: Hypromellose (derived from cellulose) capsule, Microcrystalline Cellulose, Calcium Laurate, Silicon Dioxide. *This product uses Albion’s TRAACS® Chromium Nicotinate Glycinate chelate. TRAACS is a registered trademark of Albion International, Inc. br /> **This product uses Indena S.p.A.'s saw palmetto extract (Sabalselect®). Sabalselect is a registered trademark of Indena S.p.A. Serenoa standardized to Fatty Acids 85%. Crataegus standardized to Vitexin-2"-0-rhamnoside 1.8%. V22 Suggested Use Take 4-8 capsules daily or as recommended by a health-care practitioner. Servings Per Container: 30 Warnings ALLERGY WARNING This product is contraindicated in an individual with a history of hypersensitivity to any of its ingredients. PREGNANCY WARNING If pregnant, consult your health-care practitioner before using this product. INTERACTIONS As vitamin K interferes with the effect of anticoagulant drugs (like Coumadin), the concurrent use of these agents should be avoided. Folinic acid and 5-methyltetrahydrofolate supplementation is not recommended concurrent with methotrexate cancer therapy, as they can interfere with methotrexate's anti-neoplastic activity; however, these folate sources have not been shown to interfere with the anti-inflammatory activity of methotrexate. An individual taking methotrexate for psoriasis or rheumatoid arthritis can safely take a supplement containing folate. ADDITIONAL WARNINGS Vitamin C can cause diarrhea in some individuals in large doses, which can vary from person to person and resolves when the amount is reduced. Gas, bloating, or diarrhea may occur in some individuals taking magnesium supplements. This can occur at varying amounts depending on the individual and resolves when the amount is reduced. (1)

Eight Capsules Contain: Vitamin A (12,500 IU from Mixed Carotenes and 2,500 IU as Palmitate) 15,000 IU. Vitamin C (as Ascorbic Acid) 850 mg. Vitamin D (as Vitamin D3) 1,600 IU. Vitamin E (as d-Alpha Tocopheryl) 400 IU. Vitamin K (as Vitamin K1) 100 mcg. Thiamin (as Thiamin HCl) 40 mg. Riboflavin (as Riboflavin 5'-Phosphate Sodium) 11 mg. Niacin (130 mg as Niacinamide and 30 mg as Niacin) 160 mg. Vitamin B6 (as Pyridoxal 5'-Phosphate) 16.9 mg. Folate (500 mcg as Calcium Folinate and 500 mcg as L-5-Methyltetrahydrofolate from L-5-Methyltetrahydrofolic Acid, Glucosamine Salt) 1 mg. Vitamin B12 (225 mcg as Adenosylcobalamin and 225 mcg as Methylcobalamin) 450 mcg. Biotin 400 mcg. Pantothenic Acid (as Calcium Pantothenate) 413 mg. Calcium (240 mg as Calcium Citrate and 240 mg as Citrate Malate) 480 mg. Iodine (as Potassium Iodide) 225 mcg. Magnesium (120 mg as Magnesium Citrate and 120 mg as Magnesium Malate) 240 mg. Zinc (as Zinc Picolinate) 15 mg. Selenium (as L-Selenomethionine) 200 mcg. Copper (as Copper Picolinate) 1.5 mg. Manganese (as Manganese Picolinate) 6 mg. Chromium (as TRAACS® Chromium Nicotinate Glycinate Chelate)† 200 mcg. Molybdenum (as Molybdenum Picolinate) 100 mcg. Potassium (40 mg as Potassium Citrate and 40 mg as Potassium Malate) 80 mg. Choline Citrate 100 mg. Dong Quai extract (root) (Angelica sinensis) 100 mg. Hesperidin Methyl Chalcone 75 mg. Wild Yam (root) (Dioscorea villosa) 50 mg. Boron (as Boron Picolinate) 4 mg. Vanadium (as Vanadium Picolinate) 100 mcg. Lutein (from Aztec Marigold extract (flower) (Tagetes erecta)) 192 mcg. Other Ingredients: Hypromellose (derived from cellulose) capsule, Microcrystalline Cellulose, Calcium Laurate, Silicon Dioxide. †This product uses Albion’s TRAACS® Chromium Nicotinate Glycinate chelate. TRAACS is a registered trademark of Albion International, Inc. (1)

Folate Adequate folate status is critical for maintaining optimal methylation, red blood cell balance, DNA and RNA synthesis and healthy cell division and replication. Folic acid is converted into its metabolically active form, 5-MTHF, by the enzyme methylenetetrahydrofolate reductase (5-MTHFR). 5-MTHF donates its methyl group to vitamin B12 (cobalamin), forming methylcobalamin. Methylcobalamin helps convert the problematic amino acid metabolite homocysteine into the amino acid methionine. B12 Vitamin B12 (methylcobalamin) works along with folic acid in many body processes, including the synthesis of DNA, red blood cells and supporting health of the myelin sheath, the insulating exterior that surrounds nerve cells. B12 is found primarily in animal foods. Vegetarians and the elderly are at highest risk for B12 deficiency. [2] B12 is considered by many to be a vital nutrient required to balance homocysteine levels. Methylcobalamin is the biologically active form of B12 and supports up-regulation of methylation pathways. B6 Vitamin B6 (pyridoxine) is a B vitamin that is required for more than 60 different enzymatic reactions that occur in the body. Vitamin B6 works along with folic acid and B12 for in the recycling of homocysteine. B6 also supports a healthy cardiovascular system by promoting healthy platelet aggregation and aids in maintaining healthy blood pressure. [3] Vitamin B6 is required for the activation of lysyl oxidase, an enzyme responsible for the cross-linking of collagen, and elastin, which is crucial for maintaining healthy circulation and arterial function. Trimethylglycine (Betaine) Trimethylglycine (betaine) functions in the body as a unique methyl donor, supporting liver function and detoxification pathways and the conversion of homocysteine to methionine. Trimethylglycine also works alongside B6, B12 and folic acid in maintaining normal homocysteine levels. (2)

Folate Folate is a water soluble member of the B complex vitamins that is critical for maintaining optimal methylation. Folate is found naturally in foods such as fruits and dark leafy vegetables, but can be easily destroyed by cooking or processing. Additionally, enzyme defects, malabsorption and congenital deficiency of 5-methylenetetrahydrofolate reductase (5-MTHFR), an enzyme required for the conversion of folic acid to its bioactive form 5-methyltetrahydrofolate (5-MTHF), can result in an impaired ability to activate folic acid. In individuals with a genetic defect of this enzyme, supplementation with 5-MTHF has been shown to be beneficial. 5-MTHF is required as a methyl group donor for the production of mood regulating neurotransmitters such as serotonin, the synthesis of melatonin, as well as DNA production and repair. Thiamine (Vitamin B1) While naturally abundant in whole grains, thiamine is lost in many of the over-processed grains commonly consumed today. Thiamine is an essential co-factor in the production of ATP in the cells’ Kreb's cycle, and is also needed for the metabolism of fats, proteins and carbohydrates. Riboflavin (Vitamin B2) Riboflavin is a precursor to flavin adenine dinucleodtide (FAD) and flavin mononucleotide (FMN), both of which are central to energy production, intermediary metabolism, and act as powerful antioxidants. Riboflavin-depleted cells have been found to display signs of greater oxidative stress and disrupted energy generation. Niacin Niacin is a cofactor in the mitochondrial respiratory chain, which produces cellular energy. In the body, niacin is transformed into NAD (nicotinamide adenine dinucleotide) and NADP (nicotinamide adenine dinucleotide phosphate), which both play a role in oxidation reduction reactions in cells. Vitamin B6 Vitamin B6 is involved in over 100 enzymatic reactions in the body and is essential for gluconeogenesis, lipid metabolism, neurotransmitter formation, immune health and hormone modulation, and is essential in methylation, for the breakdown of homocysteine. Vitamin B12 (Methylcobalamin) Vitamin B12, found only in organ meats, seafood and egg yolks, often becomes deficient in vegan and vegetarian diets. The vitamin is essential for the metabolism of fats and carbohydrates, the synthesis of proteins, and also plays a role in regulating mitochondrial enzymes and energy metabolism, as well as neurological health. Biotin Synthesized by the bacteria in the gut and in certain foods, biotin and its cofactors are involved in metabolism of fatty acids, amino acids and the utilization of B vitamins. Pantothenic Acid Pantothenic acid and its biologically active derivative, CoA, are essential to the synthesis of fatty acids, membrane phospholipids, amino acids, steroid hormones, and energy production. Choline Bitartrate Though not technically a B vitamin, choline is often associated with the B vitamin complex. It is important in the construction of cell membranes and plasma lipoproteins, plays a role in cell signaling and in the synthesis of acetylcholine (a neurotransmitter), and is vital for brain development. (1)

Glucosamine Glucosamine sulfate is a naturally occurring, joint-supporting compound. As a precursor to the primary building blocks of joint tissue (glycolipids, glycoproteins, hyaluronate, and proteoglycans) it is an important starting point for cartilage synthesis. Meta-analyses have long confirmed positive trends for the use of glucosamine. Chondroitin Sulfate As the major glycosaminoglycan associated with articular cartilage, chondroitin sulfate (CS) is designed to draw water into the joint tissues and hydrate them, allowing for compression when pressure is put on the joint and to rehydrate when the pressure is released. The chondroitin sulfate in Chondro-Flx is enzymatically processed providing consistently small, highly absorbed chondroitin molecules ensuring the best results. Bromelain Bromelain is a protease derived from pineapple stems that helps to maintain a normal inflammation response by affecting both the kinin and fibrin pathways. Bromelain also increases the absorption of chondroitin sulfate. (1)

Glucosamine Sulfate Glucosamine sulfate’s main physiological effect is to stimulate the production of glycosaminoglycans and promote the incorporation of sulfur into the cartilage in order for cartilage to maintain its gel-like structure and ability to act as a shock absorber. Glucosamine is the most fundamental building block for the biosynthesis of other compounds required to maintain joint health including glycolipids, glycoproteins, hyaluronate and proteoglycans. Meta-analyses have long confirmed positive findings for the use of glucosamine. (1)

Ipriflavone Isoflavones are plant-based compounds that resemble estrogen at the molecular level. In the bone tissue, isoflavones act as balanced, estrogen-like hormones which activate osteoblast cells, promoting new bone formation. Isoflavones also increase cell-signaling proteins that may inhibit the bone-absorbing activity of osteoclast cells. Ipriflavone is an isoflavone derivative which has been shown in human and animal research to support bone function and strength. Calcium Nearly 99% of the calcium within the adult skeletal system exists as a complex paired with phosphorus, called hydroxyapatite. In 1990, the USDA published a trial comparing the inexpensive calcium carbonate with calcium citrate-malate, with respect to improved bone mineral density in post-menopausal women. In this trial, researchers found the citrate-malate form was significantly better at supporting bone health than the carbonate form. OsteoPrev is formulated with calcium citrate-malate, as well as calcium hydroxyapatite, to improve calcium absorption and utilization for optimal bone support. Magnesium Magnesium plays a major role in bone formation as approximately 50% of magnesium found in the body is found in the bone. Magnesium plays numerous roles in bone health including increasing calcium absorption, acting as a cofactor for alkaline phosphatase activation, as well as supporting vitamin D3 conversion in the body. Magnesium deficiency is very common: Many Americans fail to acquire even the estimated average requirement (EAR). Magnesium deficiency can also be exacerbated due to factors such as excess consumption of alcohol, salt, coffee, phosphoric acid in sodas, and long-term stress. Vitamin D3 (Cholecalciferol) Vitamin D is a steroid vitamin known for its role in supporting bone health and aiding in the absorption of calcium and phosphate from the GI tract. Emerging research shows a direct correlation between bone mineral density and serum levels of 25(OH)D3, the active form of vitamin D. In one 2013 study, 52 overweight men and women with suboptimal vitamin D levels were given either 7,000 IU of cholecalciferol (D3) daily or a placebo for 26 weeks. The vitamin D group significantly increased vitamin D levels in the blood and improved biomarkers of bone health. Vitamin K1 (Phytonedione) & Vitamin K2 (Menaquinone) Vitamin K is responsible for synthesizing osteocalcin, a protein involved in calcium transport and properly embedding calcium into bone tissue. Vitamin K has also been shown to decrease the activity of osteoclasts, helping to maintain bone formation and strength. Vitamin K works synergistically with vitamin D3 to improve calcium absorption and helps to bind newly absorbed calcium to the bone matrix. Boron Boron supplementation reduced urinary excretion of calcium and magnesium and increased blood levels of 17 betaestradiol and testosterone in postmenopausal women. Improving boron levels has been shown to support bone health. Phosphorus Phosphorus plays a role in bone mineralization and is a component of hydroxyapatite crystals in bone. A study examining the effects of calcium intake on the absorption of dietary phosphorus found that as calcium ingestion increases, phosphorus absorption decreases. Supplementation with a calcium phosphate preparation is recommended for maintaining optimal bone mineral density and preventing calcium-induced phosphorus deficiency. (1)

Lactobacillus acidophilus (La-14)

Lactobacillus acidophilus is a beneficial bacterial strain that is normally found in the intestinal tract and mouth and is commercially used in dairy products for the production of acidophilus-type yogurt. L. acidophilus ferments various carbohydrates to produce lactic acid, which increases the absorption and bioavailability of minerals. This includes calcium, copper, magnesium and manganese. The production of lactic acid also promotes health by creating an inhospitable environment for invading microbes. L. acidophilus has been shown to protect intestinal cells by competing for adhesion space in the gut against harmful bacteria, such as E. coli. The L. acidophilus strain in Ortho Biotic has been specifically chosen because of its strong adherence and survival attributes in the GI tract. It has been demonstrated in vitro to tolerate exposure to gastric acid and bile salts, and has the ability to withstand antibiotics including Ciproflaxin, Polymyxin B and Tetracycline.

Lactobacillus paracasei (Lpc-37)

Lactobacillus paracasei has been shown to protect against the harmful effects of bacteria such as Staphylococcus aureus (S. aureus). L. paracasei colonizes the intestinal tract by reinforcing defense mechanisms that support an immune response. It does this by supporting T-helper cell production and secreting secretory IgA (sIgA), an antibody critical for supporting intestinal immunity. L. paracasei Lpc-37 is a gastric acid-resistant strain and has been shown in vitro to withstand antibiotics such as Ciproflaxin and Vancomycin. Bifidobacterium bifidum (Bb-02)

Bifidobacterium bifidum has been shown to effectively compete with harmful bacteria such as E. coli, S. aureus and Camplylobacter jejuni, which suggests B. bifidum’s lactic acid and acetic acid production provides an antagonistic action against pathogens to help maintain microflora balance.

Bifidobacterium lactis (BI-04)

Bifidobacterium lactis is predominantly found in the colon. A double-blind, randomized placebo-controlled trial on subjects receiving B. lactis or placebo for eight weeks found that B. lactis supported a balanced immune response in individuals hypersensitive to environmental allergens. Studies examining immune development and dietary supplementation with B. lactis have shown that it supports GI health by reducing intestinal permeability. Lactobacillus plantarum (Lp-115)

Lactobacillus plantarum is a beneficial bacteria commonly found in fermented foods including sauerkraut, pickles, brined olives and sourdough. L. plantarum has been found to compete against strains of Clostridium difficile and Clostridium perfringens, due to the production of bacteriocins (lethal proteins) that inhibit bacterial growth. Studies have also demonstrated that L. plantarum helps boost the immune response by stimulating Th1-mediated immunity.

Lactobacillus rhamnosus (Lr-32)

Lactobacillus rhamnosus has been proven to have remarkable survivability in the acid and bile environments in the GI tract. L. rhamnosus is particularly useful because of its ability to adhere to cells, enhance microflora balance, and inhibit pathogen adherence. L. rhamnosus was also found to positively affect inflammatory and immune gene signaling of over 1,700 genes when administered in high doses.

Saccharomyces boulardii

Saccharomyces boulardii is a probiotic yeast that was first isolated from the skin of the tropical fruits lychee and mangosteen in 1923 by French scientist Henri Boulard, following the observation that mangosteen consumption controlled occasional diarrhea in natives of Southeast Asia. S. boulardii plays a role in supporting immune defense by increasing levels of sIgA, creating a first line of defense that helps bind and clear harmful bacteria. (2)

Magnesium & Potassium Bioavailability – The Mineral Chelate Difference The importance of bioavailability is obvious. If consuming a mineral supplement has little effect on improving the body’s mineral balance, there is no reason to ingest it. Signs of inferior mineral supplements include the use of cheap, poorly absorbed, rock-salt minerals like calcium carbonate and magnesium oxide. These mineral forms slow and limit absorption, relying on adequate stomach acid to release magnesium ions which then enter the body via passive diffusion. And, because they tend to remain in the intestines longer, these forms of mineral supplements can cause intestinal distress such as constipation (calcium carbonate) or diarrhea (magnesium oxide). Reacted Magnesium & Potassium provides the additional benefit of highly absorbed, Albion® mineral chelates. Albion® is the world leader in manufacturing highly bioavailable mineral chelates, a specialized form of minerals bound to amino acids. This patented process creates organic mineral compounds which use active absorption mechanisms in the gastrointestinal tract to greatly enhance mineral absorption. In a magnesium comparison study reported by Graff et al. at Weber State University, Albion®’s magnesium amino acid chelate had: 8.8 times greater absorption than magnesium oxide 5.6 times greater absorption than magnesium sulfate 2.3 times greater absorption than magnesium carbonate In addition, other comparison studies have shown significantly superior absorption of magnesium chelates compared to other mineral forms: At a dose of 400 mg, magnesium chelate significantly reduced or eliminated menstrual abdominal discomfort. Multiple double blind studies found urinary excretion of magnesium chloride higher than magnesium glycinate, proving superior absorption. Magnesium glycinate is shown to have a reduced laxative effect when compared to other forms of magnesium. Mineral chelates are gentle, gut “friendly” minerals that do not cause diarrhea that often accompanies magnesium oxide and other rock-salt forms. Albion’s mineral chelates have extensive clinical research proving their superior bioavailability, biologic activity, stability and improved tolerance. Magnesium Magnesium is an abundant mineral in the body that is found naturally in many foods, like green leafy vegetables. It is also found in over-the-counter medications, such as laxatives. The average American intake of magnesium, according to the National Health and Nutrition Examination Survey (NHANES Study) is critically low: Many Americans fail to consume the estimated average requirement (EAR) established by the Institute of Medicine. In addition, more than 57% of the population does not meet the United States Deparment of Agriculture requirements for magnesium in their diet. Intracellular magnesium levels are decreased by excessive intake of alcohol, salt, coffee, phosphoric acid found in sodas, diets high in calcium, and high stress levels. Because of the widespread nature of magnesium deficiencies, adequate daily intake of magnesium is critical for proper hydration, stress response, muscle relaxation, promoting healthy blood pressure levels, optimal bone mineral density, and blood sugar regulation. (1)

Marine lipid concentrate [fish (sardine, anchovy, and mackerel) oil], softgel shell (gelatin, glycerin, water), natural lemon flavor, natural lime flavor, mixed tocopherols (antioxidant), rosemary extract, and ascorbyl palmitate (antioxidant). Contains: Fish (sardine, anchovy, and mackerel). (2)

Methylsulfonylmethane (MSM) Sulfur is an essential element for all of life and is naturally found in foods such as garlic and onions, as well as protein-rich foods, such as poultry, fish and eggs. Sulfur ranks as the third-highest substance by weight in the body’s chemistry, behind water and gases, and plays a major role in maintaining the body’s overall health. In recent years, the typical American diet has progressively declined in sulfur content, leaving many susceptible to depletion. The concentration of MSM in the body also decreases with age, making it difficult for the body to generate new cells. MSM contains about 34% sulfur by weight, making it an ideal supplement for those that want to naturally increase their sulfur levels and obtain its significant health benefits. (1)

Mineral Bioavailability – The Mineral Chelate Difference The importance of bioavailability is obvious. If consuming a calcium supplement has little effect on improving the body’s calcium balance, there is no reason to ingest it. Signs of inferior mineral supplements include the use of cheap, poorly absorbed, rock-salt minerals like calcium carbonate and magnesium oxide. These mineral forms slow and limit absorption, relying on adequate stomach acid to release calcium ions which then enter the body via passive diffusion. And, because they tend to remain in the intestines longer, these forms of mineral supplements can cause intestinal distress such as constipation (calcium carbonate) or diarrhea (magnesium oxide). Reacted MultiMin provides the benefit of highly-absorbed, Albion® mineral chelates. Albion® is the world leader in manufacturing highly bioavailable mineral chelates, a specialized form of minerals bound to amino acids. This patented process creates organic mineral compounds which use active absorption mechanisms in the gastrointestinal tract to greatly enhance mineral absorption. Comparison studies have shown significantly superior absorption of mineral chelates compared to other mineral forms. In a clinical study specifically comparing calcium absorption in humans, Albion®’s patented calcium chelate delivered the greatest absorption of all calcium sources tested. Calcium from calcium carbonate is often absorbed at very low levels (less than 10%). In a human clinical study, Albion®’s patented calcium chelate formulation averaged 44% absorption of the dose without the benefit of meal enhancement. No other calcium form has an equivalent or higher rate of absorption. In addition, mineral chelates are gentle, gut “friendly” minerals that do not cause constipation that often accompanies calcium carbonate and other rock-salt forms. Albion®’s mineral chelates have extensive clinical research proving their superior bioavailability, biologic activity, stability, and improved tolerance. Calcium Calcium is required for heart health, muscle function, nerve transmission, intracellular signaling and hormonal secretion. It is less than 1% of total body calcium that supports these critical metabolic functions. Serum calcium is very tightly regulated and does not fluctuate with changes in dietary intakes. The body uses bone tissue as a reservoir for calcium, as well as a source of calcium, to maintain constant concentrations of calcium in blood, muscle and intercellular fluids. The remaining 99% of the calcium supply in the body is stored in the bones and teeth, serving as support for their structure and function. Magnesium More than 57% of the population does not meet the United States Department of Agriculture requirements for magnesium in their diet. Magnesium is a cofactor in over 300 enzyme systems and is integral to many processes in the body, including protein synthesis, muscle and nerve function, and maintaining blood glucose control and blood pressure regulation. It contributes to the structural development of bone and is required for the synthesis of DNA, RNA and the antioxidant, glutathione. Magnesium also plays a role in the active transport of calcium and potassium ions across cell membranes, a process that is important to nerve impulse conduction, muscle contraction and normal heart rhythm. Zinc Zinc is fundamental to the activity of over 100 enzymes and supports immune function, protein synthesis, tissue regeneration and healing, DNA synthesis and cell division. During pregnancy, infancy and childhood, the body needs zinc for proper growth and development. Zinc also helps boost tissue repair and is important to adequate functioning of the senses of taste and smell. Daily intake of zinc is necessary to maintain adequate levels within the body because the body has no specialized zinc storage system. Selenium Selenium has structural roles, as well as enzymatic functions. It is best-known as an antioxidant and catalyst in the production of active thyroid hormone. Selenium is essential in the balance and support of immune system function. Selenium promotes sperm motility, supports positive mood, antioxidant status, inflammation balance and heart health. Potassium Potassium is an electrolyte mineral that carries an electric charge. It is critical to maintaining electrolyte balance in the body. Potassium can contribute to heart and bone health and is an integral part of muscle contraction and muscle building. (1)

N-Acetyl Cysteine N-acetyl cysteine (NAC) is a powerful amino acid that dissolves mucus by breaking up disulfide bonds which make up the protein network that contributes to mucus density. This results in improved drainage out of the sinus cavity. In a double-blind study examining 12 healthy volunteers with slow mucociliary clearance, NAC administration for 60 days resulted in a 35% increase in mucociliary clearance rate in treated subjects, compared to no improvement in the placebo group. Additional studies have also demonstrated an improvement in mucus clearance following NAC administration. Turmeric Root Extract Curcumin is a yellow-colored plant pigment found in the spice, turmeric. Sinatrol contains turmeric which is standardized to contain 95% curcumin. Research shows that curcumin affects numerous molecules that support healthy inflammatory response. Bromelain Bromelain is a plant enzyme that is naturally found in the stem and fruit of the pineapple plant. Bromelain exerts a synergistic effect when combined with NAC due to its proteolytic (protein-digesting) effects. Bromelain has been shown to be effective at thinning nasal secretions and provides an additional benefit of balancing inflammatory response. Berberine Sulfate Hydrate Berberine sulfate is a botanical extract found in the roots and barks of various plants including Oregon grape root, barberry and goldenseal. Berberine extract has been shown to support immune response by increasing blood flow to the spleen and by activating immune compounds such as macrophages. Berberine maintains healthy sinus function by quieting localized inflammatory response- Berberine has been shown to inhibit activator protein 1 (AP-1) and inhibits thromboxane A2 from platelets. Licorice Root Extract Licorice root has been used in Western and Eastern cultures for thousands of years. Licorice’s health-promoting benefits include soothing respiratory irritation. The active components in licorice, glycyrrhizin and glycyrrhetinic acid, strengthen immune response by inducing interferon activity, activating macrophages and augmenting natural killer cell activity. Glycyrrhizin exerts its inflammatory balancing response by inhibiting the production of reacted oxygen species released by neutrophils. Andrographis Andrographis paniculata is a plant that has been used in Asian medicine for centuries. The immune boosting properties of andrographis have been research extensively in clinical studies- Per the analysis of seven double-blind controlled trials, andrographis has been shown to be a safe botanical for supporting upper respiratory tract health. Eleuthero Recent studies utilizing the combination of Eleuthero and Andrographis have demonstrated the combination of herbs to be particularly helpful for patients with upper respiratory challenges. Thyme Thyme has been traditionally used to help soothe sinuses and loosen phlegm. Thymol, the active ingredient in thyme, also has immune supporting properties and competes with pathogens commonly found throughout the sinuses and respiratory tract. The German Commission E has approved thyme to help support respiratory challenges. (1)

N-Acetyl Cysteine N-acetyl cysteine is a source of the conditionally essential amino acid L-cysteine and is a precursor to the tripeptide glutathione, an essential intracellular antioxidant, and therefore supports antioxidant and cellular detoxification pathways in the body. (1)

Neo40 Ingredients: Vitamin C, Vitamin B12, Proprietary Nitric Oxide Blend (Beet Root Powder (root), Hawthorn Berry Extract (berry), L-citruline, Sodium Nitrite. Other Ingredients: mannitol, modified cellulose, xylitol, natural flavors, magnesium vegetable stearate, stevia, silica. (1)

Niacin Niacin is most well-known for its broad cardiovascular benefits, but is also an important nutrient for bone health, blood sugar balance, as well as cerebrovascular function. Populations that consume adequate levels of niacin have been shown to have better outcomes for long-term health. Time Release Formula The proprietary, natural wax-matrix coating technology used in the Time Release Niacin formula allows for release over a seven to eight hour period to reduce flushing. In a double-blind, placebo-controlled study, this formula has only a 5-7% flush rate, making it well-tolerated and highly effective for supporting balanced cholesterol levels. (1)

One (5 mL) Teaspoon Contains: Calories 45 Calories from Fat 45 Total Fat 4.5 g Saturated Fat 1.5 g Trans Fat 0 g EPA (Eicosapentaenoic Acid)* 700 mg DHA (Docosahexaenoic Acid)* 440 mg Other Ingredients: Flavors, Sunflower Lecithin, Mixed Tocopherols (non-GMO), Astaxanthin, Rosemary extract (Rosmarinos officinalis), Monk Fruit concentrate (fruit) (Siraitia grosvenorii), Ascorbyl Palmitate. *Contains ingredients derived from fish (fish oil = anchovy, sardine, mackerel). The fish oil in this product is in the triglyceride form. Refrigerate after opening. (1)

One Capsule Contains: Bacillus coagulans* 133 mg. Other Ingredients: Microcrystalline Cellulose, Hypromellose (derived from cellulose) capsule, Silicon Dioxide. *Lactobacillus sporogenes (alternate nomenclature). Contains a minimum of 2 billion CFUs per capsule. (1)

One Capsule Contains: Saccharomyces boulardii* 250 mg Other Ingredients: Hypromellose (derived from cellulose) capsule, Silicon Dioxide. *Contains a minimum of 5 billion CFUs per capsule. (1)

One Capsule Contains: Thiamin (as Thiamin HCl) 50 mg Riboflavin (25 mg as Riboflavin and 3.6 mg as Riboflavin 5'-Phosphate Sodium) 28.6 mg Niacin (as Niacinamide) 80 mg Vitamin B6 (25 mg as Pyridoxine HCl and 3.4 mg as Pyridoxal 5'-Phosphate) 28.4 mg Folate (as L-5-Methyltetrahydrofolate* from L-5-Methyltetrahydrofolic Acid, Glucosamine Salt) 200 mcg Vitamin B12 (as Methylcobalamin) 100 mcg Biotin 80 mcg Pantothenic Acid (as Calcium Pantothenate) 250 mg Choline Citrate 40 mg Other Ingredients: Hypromellose (derived from cellulose) capsule, Microcrystalline Cellulose, Calcium Laurate, Silicon Dioxide. *This product uses Gnosis S.p.A.'s L-5-Methyltetrahydrofolic Acid, Glucosamine Salt. (1)

One Capsule Contains: Vitamin B12 (as Methylcobalamin) 1 mg. Other Ingredients: Microcrystalline Cellulose, Hypromellose (derived from cellulose) capsule, Leucine, Silicon Dioxide. (1)

One Capsule Contains: Vitamin D (as Vitamin D3) 1,000 IU Other Ingredients: Microcrystalline Cellulose, Hypromellose (derived from cellulose) capsule, Vitamin E (mixed tocopherols), Leucine, Silicon Dioxide. (1)

One Capsule Contains: Vitamin D (as Vitamin D3) 10,000 IU. Other Ingredients: Microcrystalline Cellulose, Hypromellose (derived from cellulose) capsule, Leucine, Silicon Dioxide, Vitamin E (d-Alpha Tocopheryl). (1)

One Capsule Contains: Vitamin D (as Vitamin D3) 5,000 IU Other Ingredients: Microcrystalline Cellulose, Hypromellose (derived from cellulose) capsule, Leucine, Silicon Dioxide, Vitamin E (d-Alpha Tocopheryl). (1)

One Capsule Contains: Proprietary Blend 5 Billion Live Cells* Lactobacillus gasseri KS-13 Bifidobacterium longum MM-2 Bifidobacterium bifidum G9-1 Other Ingredients: Hypromellose (derived from cellulose) capsule, Potato Starch, Silica. *At time of expiration. Does not require refrigeration. (1)

One Capsule Contains:

Thiamin (as Thiamin HCl) 110 mg.
Riboflavin (as Riboflavin 5'-Phosphate Sodium) 10 mg.
Niacin (130 mg as Niacinamide and 10 mg as Niacin) 140 mg.
Vitamin B6 (as Pyridoxal 5'-Phosphate) 10 mg.
Folate (400 mcg as L-5-Methyltetrahydrofolate† from L-5-Methyltetrahydrofolic Acid,Glucosamine Salt) 667 mcg DFE
Vitamin B12 (as Methylcobalamin) 400 mcg.
Biotin 400 mcg.
Pantothenic Acid (as Calcium Pantothenate) 110 mg.
Choline (as Choline Citrate) 28 mg.

Other Ingredients: Hypromellose (derived from cellulose) capsule, Microcrystalline Cellulose, Calcium Laurate, Leucine, Magnesium Citrate, Silicon Dioxide.

†This product uses Gnosis S.p.A.'s L-5-Methyltetrahydrofolic Acid,Glucosamine Salt (Quatrefolic®). Quatrefolic is a registered trademark of Gnosis S.p.A. (1)

One Capsule Contains:

Folate (1 mg as L-5-Methyltetrahydrofolate†) 1.7 mg DFE

Other Ingredients: Microcrystalline Cellulose, Hypromellose (derived from cellulose) capsule, Leucine, Silicon Dioxide.

†This product uses Gnosis S.p.A.'s L-5-Methyltetrahydrofolate (Extrafolate-S®). Extrafolate-S is a registered trademark of Gnosis S.p.A. (1)

One Capsule Contains:

Folate (5 mg as L-5-Methyltetrahydrofolate†) 8.3 mg DFE

Other Ingredients: Microcrystalline Cellulose, Hypromellose (derived from cellulose) capsule, Leucine, Silicon Dioxide.

†This product uses Gnosis S.p.A.'s L-5-Methyltetrahydrofolate (Extrafolate-S®). Extrafolate-S is a registered trademark of Gnosis S.p.A. (1)

One Capsule Contains:

Thiamin (as Thiamin HCl) 40 mg.
Riboflavin (25 mg as Riboflavin and 3.6 mg as Riboflavin 5'-Phosphate Sodium) 28.6 mg.
Niacin (as Niacinamide) 80 mg.
Vitamin B6 (20 mg as Pyridoxine HCl and 3.4 mg as Pyridoxal 5'-Phosphate) 23.4 mg.
Folate (200 mcg as Calcium Folinate and 200 mcg as L-5-Methyltetrahydrofolate† from L-5-Methyltetrahydrofolic Acid, Glucosamine Salt) 668 mcg DFE
Vitamin B12 (300 mcg as Adenosylcobalamin and 300 mcg as Methylcobalamin) 600 mcg.
Biotin 80 mcg.
Pantothenic Acid (as Calcium Pantothenate) 45 mg.
Choline (as Choline Citrate) 14 mg.

Other Ingredients: Hypromellose (derived from cellulose) capsule, Microcrystalline Cellulose, Calcium Laurate, Silicon Dioxide.

†This product uses Gnosis S.p.A.'s L-5-Methyltetra-hydrofolic Acid, Glucosamine Salt (Quatrefolic®). Quatrefolic is a registered trademark of Gnosis S.p.A. (1)

One Gelcap Contains: Calories 10 Calories from Fat 10 Total Fat 1 g EPA (Eicosapentaenoic Acid) (from Fish Oil) 300 mg. DHA (Docosahexaenoic Acid) (from Fish Oil) 200 mg. GLA (Gamma Linolenic Acid) (from Borage Oil) 40 mg. Other Ingredients: Gelatin (bovine), Purified Water and Glycerin (vegetable source) gelcap, Vitamin E (mixed tocopherols). Contains ingredients derived from fish (fish oil = anchovy, sardine, mackerel). (1)

One Gelcap Contains:

Calories 10
Total Fat 1 g
EPA (Eicosapentaenoic Acid) (from Fish Oil) 425 mg
DHA (Docosahexaenoic Acid) (from Fish Oil) 270 mg

Other Ingredients: Gelatin (bovine), Purified Water and Glycerin (vegetable source) gelcap, Vitamin E (mixed tocopherols).
Contains ingredient derived from fish (fish oil = anchovy). (1)

One Scoop (29.2 g) Contains:

Calories 100
Total Fat 1 g
Saturated Fat 0.5 g
Cholesterol 10 mg
Total Carbohydrate 4 g
Dietary Fiber 1 g
Total Sugars 2 g
Includes 1 g Added Sugars
Protein 21 g
Calcium 69 mg
Iron 1 mg
Sodium 105 mg
Potassium 200 mg
Proprietary Blend 30 mg
Bromelain
Papain††

Other Ingredients: Whey Protein Isolate, Alkalized Cocoa Powder, Flavors, Sunflower Lecithin, Evaporated Cane Juice Sugar, Stevia extract (leaf) (Rebaudioside A 95%), Xanthan Gum, Carboxymethylcellulose Gum.Contains ingredient derived from milk (whey protein isolate).

†Bromelain is derived from the pineapple plant (Ananas comosus).

†† An enzyme derived from Papaya (Carica papaya).

Typical Amino Acid Amounts (g) Per Serving:
Alanine 1.0
Arginine 0.6
Aspartic Acid 2.1
Cysteine 0.5
Glutamic Acid 3.6
Glycine 0.4
Histidine 0.4
Isoleucine 1.2
Leucine 2.2
Lysine* 1.9
Methionine* 0.5
Phenylalanine* 0.7
Proline 1.2
Serine 1.1
Threonine* 1.4
Tryptophan* 0.4
Tyrosine 0.6
Valine* 1.2

*Essential Amino Acid (2)

Per 2 Capsules:

Vitamin C (as Ascorbic Acid USP) - 700mg
Calcium (as Calcium Carbonate USP) - 100mg
Magnesium (as Magnesium Carbonate USP) - 100mg
Potassium (as Potassium Gluconate USP) - 20mg (1)

Pregnenolone Pregnenolone plays a key role in hormonal balance as a key precursor to cortisol, DHEA and progesterone, and helps to maintain balance in the body’s stress response system. In addition to its function as a prohormone, pregnenolone is a neurosteroid that is found in high concentrations in the brain where it protects neurons, enhances myelination and supports cognitive health and memory. Pregnenolone supplementation is particularly important for those who have been found to have deficient hormone levels through testing, as well as those who need cortisol to DHEA ratio support. (1)

Psyllium Husks and Seeds Several clinical trials have shown psyllium to be superior to other laxatives. A systematic review found psyllium husk to improve overall bowel regularity more effectively than lactulose. Psyllium has been found to be effective at increasing stool output and was found to improve the symptoms of occasional constipation increasing abdominal comfort and a sense of evacuation completeness, while reducing defecation effort. A randomized controlled trial found psyllium to have a significant effect among those with bowel irregularity and discomfort. After three months, symptom severity in the psyllium group was reduced by 90 points, compared with 49 in the placebo group. The laxative effect and gut-stimulatory effect of psyllium has been purported to be facilitated partially by muscarinic and 5-HT(4) receptor activation, which complements the laxative effect of psyllium’s fiber content. In addition, studies have also found that a 15 g dose of psyllium given 3 times per day before meals promotes healthy blood sugar and blood lipid levels. Rice Bran In one animal study, giving 10 g per day of rice bran, including water soluble rice bran and rice bran fiber concentrates, resulted in significantly enhanced blood sugar balance and fasting blood sugar and lipid levels were maintained in the normal range. The extracts of rice bran have also been found to support cardiovascular health, a balanced inflammatory response, and a healthy colonic environment. Apple Pectin A meta-analysis of randomized controlled trials showed consumption of several grams a day of pectin promotes healthy blood fats and maintains cholesterol levels already within a normal range. Liver fat concentrations have been found to be lower in rats fed diets containing apple pectin; fecal bile acid excretion was also found to be reduced, and sterol excretion significantly increased with the addition of pectin. Rats fed pectin rich diets also had lower levels of certain blood fats than controls. Fig (Ficus carica) The phytochemical properties of Fig’s laxative effect are due to the bulk of seeds and fibers. In a double-blind, randomized controlled study of 20 patients with occasional functional bowel irregularity, supplementation with fig fruit increased frequency, reduced defecation time, improved abdominal comfort and heightened a sense of complete evacuation. Fig fruit supplementation also improved the symptoms of occasional irregularity, and the fruit has also been shown to maintain bulk in those with loose stools. Prune (Prunus domestica) Prunes or dried prunes contain 6.1 g of dietary fiber per 100 g, as well as large amounts of phenolic compounds which may aid in their efficacy for occasional constipation and glycemic support. The phenolic compounds in prunes have been found to inhibit oxidation of certain blood fat components in vitro, and thus may protect against oxidative damage; In addition, prunes have a high concentration of potassium and have been shown to support blood pressure and cardiovascular health. Another study found that 50 g of prunes, two times a day were found to be effective in helping with occasional constipation in 40 subjects enrolled in an 8-week study compared to psyllium. (1)

Quercetin Quercetin has strong antioxidant activity and has been shown to support immune health by mediating the release of inflammatory compounds including leukotrienes and prostaglandins. Quercetin is known for its ability to stabilize mast cells, diminishing the release of histamine, the compound known to cause hypersensitivity reactions during seasonal changes. Stinging Nettles Leaf Extract Stinging nettles leaf is a plant that has been shown to balance immune response, specifically in the airways and nasal passages. Studies have shown that the extract of stinging nettles leaf balances a variety of inflammatory activities that affect respiratory health. Bromelain Bromelain is a plant enzyme naturally found on the stem and fruit of the pineapple plant. Bromelain is a proteolytic (protein-digesting) enzyme that aids in in the breakdown of large protein complexes, including antigenic compounds, and has been shown to enhance the absorption of quercetin. Bromelain has been shown to reduce circulating allergenic protein complexes associated with hyper-immune sensitivity and seasonal discomfort. N-Acetyl Cysteine N-acetyl cysteine (NAC) is an amino acid precursor to one of the most important antioxidants in the body, glutathione. Both glutathione and NAC help reduce the viscosity of the mucus allowing for clearing of the airways and improved respiratory health. Vitamin C Vitamin C cannot be synthesized by humans and is therefore an essential nutrient that must be consumed in the diet. Among its numerous health-promoting properties, vitamin C is an essential vitamin that supports the immune system and is also a potent antioxidant. When the body is under a significant amount of stress, vitamin C is excreted rapidly. Vitamin C has many immune boosting properties, but is distinctively beneficial for individuals with seasonal discomfort because of its ability to deactivate histamine. (1)

Six Capsules Contain: Vitamin A (12,500 IU from Beta Carotene and 2,500 IU as Palmitate) 15,000 IU Vitamin C (as Ascorbic Acid) 850 mg. Vitamin D (as Vitamin D3) 1,000 IU Vitamin E (as d-Alpha Tocopheryl) 400 IU Thiamin (as Thiamin HCl) 40 mg. Riboflavin (as Riboflavin 5'-Phosphate Sodium) 11 mg. Niacin (130 mg as Niacinamide and 30 mg as Niacin) 160 mg. Vitamin B6 (as Pyridoxal 5'-Phosphate) 10 mg. Folate (500 mcg as Calcium Folinate and 500 mcg as L-5-Methyltetrahydrofolate from L-5-Methyltetrahydrofolic Acid, Glucosamine Salt) 1 mg. Vitamin B12 (225 mcg Adenosylcobalamin and 225 mcg as Methylcobalamin) 450 mcg. Biotin 400 mcg. Pantothenic Acid (as Calcium Pantothenate) 413 mg. Calcium (120 mg as Calcium Citrate and 90 mg as Calcium Malate) 210mg. Iodine (as Potassium Iodide) 225 mcg. Magnesium (120 mg as Magnesium Citrate and 60 mg as Magnesium Malate) 180mg. Zinc (as Zinc Picolinate) 15 mg. Selenium (as L-Selenomethionine) 200 mcg. Copper (as Copper Picolinate) 1.5 mg. Manganese (as Manganese Picolinate) 6 mg. Chromium (as Chromium Nicotinate Glycinate Chelate) 200 mcg. Molybdenum (as Molybdenum Picolinate) 100 mcg. Potassium (30 mg as Potassium Citrate and 30 mg as Potassium Malate) 60 mg. Choline Citrate 100 mg. Hesperidin Methyl Chalcone 100 mg. Coenzyme Q10 50 mg. Glutathione (Reduced) 50 mg. R-Lipoic Acid (as Sodium R-Lipoic Acid)* 5 mg. Boron (as Boron Picolinate) 3 mg. Lutein (from Aztec Marigold extract (flower) (Tagetes erecta))144 mcg. Vanadium (as Vanadium Picolinate) 100 mcg. Other Ingredients: Hypromellose (derived from cellulose) capsule, Calcium Laurate, Silicon Dioxide, Microcrystalline Cellulose. *This product uses GeroNova Research's Bio-Enhanced® R-Lipoic Acid. Bio-Enhanced is a registered trademark of GeroNova Resarch, Inc. (1)

Six Capsules Contain: Vitamin A (12,500 IU from Beta Carotene and 2,500 IU as Palmitate) 15,000 IU. Vitamin C (as Ascorbic Acid) 850 mg. Vitamin D (as Vitamin D3) 1,000 IU. Vitamin E (as d-Alpha Tocopheryl) 400 IU. Thiamin (as Thiamin HCl) 40 mg. Riboflavin (as Riboflavin 5'-Phosphate Sodium) 11 mg. Niacin (130 mg as Niacinamide and 30 mg as Niacin) 160 mg. Vitamin B6 (as Pyridoxal 5'-Phosphate) 10 mg. Folate (500 mcg as Calcium Folinate and 500 mcg as L-5-Methyltetrahydrofolate from L-5-Methyltetrahydrofolic Acid, Glucosamine Salt) 1 mg. Vitamin B12 (225 mcg as Adenosylcobalamin and 225 mcg as Methylcobalamin) 450 mcg. Biotin 400 mcg. Pantothenic Acid (as Calcium Pantothenate) 413 mg. Calcium (120 mg as Calcium Citrate and 90 mg as Calcium Malate) 210 mg. Iron (as Iron Picolinate) 15 mg. Iodine (as Potassium Iodide) 225 mcg. Magnesium (90 mg as Magnesium Citrate and 60 mg as Magnesium Malate) 150 mg. Zinc (as Zinc Picolinate) 15 mg. Selenium (as L-Selenomethionine) 200 mcg. Copper (as Copper Picolinate) 1.5 mg. Manganese (as Manganese Picolinate) 6 mg. Chromium (as TRAACS® Chromium Nicotinate Glycinate Chelate)* 200 mcg. Molybdenum (as Molybdenum Picolinate) 100 mcg. Potassium (30 mg as Potassium Citrate and 30 mg as Potassium Malate) 60 mg. Choline Citrate 100 mg. Boron (as Boron Picolinate) 3 mg. Lutein (from Aztec Marigold extract (flower) (Tagetes erecta)) 144 mcg. Vanadium (as Vanadium Picolinate) 100 mcg. Other Ingredients: Hypromellose (derived from cellulose) capsule, Microcrystalline Cellulose, Calcium Laurate, Silicon Dioxide. *This product uses Albion’s TRAACS® Chromium Nicotinate Glycinate chelate. TRAACS is a registered trademark of Albion Laboratories International, Inc. V21 (1)

Six Capsules Contain: Vitamin A (12,500 IU from Beta Carotene and 2,500 IU as Palmitate) 15,000 IU. Vitamin C (as Ascorbic Acid) 850 mg. Vitamin D (as Vitamin D3) 1,000 IU. Vitamin E (as d-Alpha Tocopheryl) 400 IU. Thiamin (as Thiamin HCl) 40 mg. Riboflavin (as Riboflavin 5'-Phosphate Sodium) 11 mg. Niacin (130 mg as Niacinamide and 30 mg as Niacin) 160 mg. Vitamin B6 (as Pyridoxal 5'-Phosphate) 10 mg. Folate (500 mcg as Calcium Folinate and 500 mcg as L-5-Methyltetrahydrofolate from L-5-Methyltetrahydrofolic Acid, Glucosamine Salt) 1 mg. Vitamin B12 (225 mcg as Adenosylcobalamin and 225 mcg as Methylcobalamin) 450 mcg. Biotin 400 mcg. Pantothenic Acid (as Calcium Pantothenate) 413 mg. Calcium (as Calcium Citrate) 240 mg. Iodine (as Potassium Iodide) 225 mcg. Magnesium (as Magnesium Citrate) 180 mg. Zinc (as Zinc Picolinate) 15 mg. Selenium (as L-Selenomethionine) 200 mcg. Manganese (as Manganese Picolinate) 6 mg. Chromium (as Chromium Nicotinate Glycinate Chelate) 200 mcg. Molybdenum (as Molybdenum Picolinate) 100 mcg. Potassium (as Potassium Citrate) 60 mg. Choline Citrate 100 mg. Boron (as Boron Picolinate) 3 mg. Lutein (from Aztec Marigold extract (flower) (Tagetes erecta)) 144 mcg. Vanadium (as Vanadium Picolinate) 100 mcg. Other Ingredients: Hypromellose (derived from cellulose) capsule, Microcrystalline Cellulose, Silicon Dioxide. (1)

Six Capsules Contain: Vitamin A (12,500 IU from Beta Carotene and 2,500 IU as Palmitate) 15,000 IU. Vitamin C (as Ascorbic Acid) 850 mg. Vitamin D (as Vitamin D3) 1,000 IU. Vitamin E (as d-Alpha Tocopheryl) 400 IU. Vitamin K (as Vitamin K1) 100 mcg. Thiamin (as Thiamin HCl) 40 mg. Riboflavin (as Riboflavin 5'-Phosphate Sodium) 11 mg. Niacin (130 mg as Niacinamide and 30 mg as Niacin) 160 mg. Vitamin B6 (as Pyridoxal 5'-Phosphate) 10 mg. Folate (500 mcg as Calcium Folinate and 500 mcg as L-5-Methyltetrahydrofolate† from L-5-Methyltetrahydrofolic Acid, Glucosamine Salt) 1 mg. Vitamin B12 (225 mcg as Adenosylcobalamin and 225 mcg as Methylcobalamin) 450 mcg. Biotin 350 mcg. Pantothenic Acid (as Calcium Pantothenate) 413 mg. Calcium (120 mg as Calcium Citrate and 90 mg as Calcium Malate) 210 mg. Magnesium (90 mg as Magnesium Citrate and 60 mg as Magnesium Malate) 150 mg. Zinc (as Zinc Picolinate) 15 mg. Selenium (as L-Selenomethionine) 200 mcg. Copper (as Copper Picolinate) 1.5 mg. Manganese (as Manganese Picolinate) 6 mg. Chromium (as TRAACS® Chromium Nicotinate Glycinate Chelate)†† 200 mcg. Molybdenum (as Molybdenum Picolinate) 100 mcg. Potassium (30 mg as Potassium Citrate and 30 mg as Potassium Malate) 60 mg. Choline Citrate 100 mg. Boron (as Boron Picolinate) 3 mg. Lutein (from Aztec Marigold extract (flower) (Tagetes erecta)) 144 mcg. Vanadium (as Vanadium Picolinate) 100 mcg. Other Ingredients: Hypromellose (derived from cellulose) capsule, Microcrystalline Cellulose, Calcium Laurate, Silicon Dioxide. †This product uses Gnosis S.p.A.’s L-5-Methyltetrahydrofolic Acid, Glucosamine Salt (Quatrefolic®). Quatrefolic is a registered trademark of Gnosis S.p.A. ††This product uses Albion’s TRAACS® Chromium Nicotinate Glycinate Chelate. TRAACS is a registered trademark of Albion International, Inc. (1)

Six Capsules Contain: Vitamin A (3,750 IU from Beta Carotene and 750 IU as Palmitate) 4,500 IU. Vitamin C (as Ascorbic Acid) 250 mg. Vitamin D (as Vitamin D3) 400 IU. Vitamin E (as d-Alpha Tocopheryl) 120 IU. Vitamin K (as Vitamin K1) 30 mcg. Thiamin (as Thiamin HCl) 12 mg. Riboflavin (as Riboflavin 5'-Phosphate Sodium) 3.3 mg. Niacin (40 mg as Niacinamide and 9 mg as Niacin) 49 mg. Vitamin B6 (as Pyridoxal 5'-Phosphate) 3 mg. Folate (200 mcg as Calcium Folinate and 200 mcg as L-5-Methyltetrahydrofolate from L-5-Methyltetrahydrofolic Acid, Glucosamine Salt) 400 mcg. Vitamin B12 (67.5 mcg as Adenosylcobalamin and 67.5 mcg as Methylcobalamin) 135 mcg. Biotin 120 mcg. Pantothenic Acid (as Calcium Pantothenate) 124 mg. Calcium (34.5 mg as Calcium Citrate and 34.5 mg as Calcium Malate) 69 mg. Iron (as Iron Picolinate) 4.5 mg. Iodine (as Potassium Iodide) 67.5 mcg. Magnesium (22.5 mg as Magnesium Citrate and 22.5 mg as Magnesium Malate) 45 mg. Zinc (as Zinc Picolinate) 4.5 mg. Selenium (as L-Selenomethionine) 60 mcg. Copper (as Copper Picolinate) 450 mcg. Manganese (as Manganese Picolinate) 1.8 mg. Chromium (as TRAACS® Chromium Nicotinate Glycinate Chelate)* 60 mcg. Molybdenum (as Molybdenum Picolinate) 30 mcg. Potassium (as Potassium Citrate-Malate) 27 mg. Choline Citrate 30 mg. Boron (as Boron Picolinate) 900 mcg. Lutein (from Aztec Marigold extract (flower) (Tagetes erecta)) 36 mcg. Vanadium (as Vanadium Picolinate) 30 mcg. Other Ingredients: Hypromellose (derived from cellulose) capsule, Microcrystalline Cellulose, Calcium Laurate, Silicon Dioxide. This product uses Albion’s TRAACS® Chromium Nicotinate Glycinate chelate. TRAACS is a registered trademark of Albion International, Inc. (1)

Skullcap An extract of the root of Scutellaria baicalensis, this popular Chinese botanical has been shown to modulate viral activity and support cardiovascular health. Skullcap possesses potent antioxidant properties, and research has shown it attenuates NFkB and inhibits COX-2 expression. According to a recent study, the botanical boosts immune response to certain pathogens and supports normal respiration by protecting airways and preserving normal mitochondrial function. Propolis Bees create propolis by collecting a resinous sap from trees and then mixing it with wax within the hive. Propolis has a diverse variety of potent terpenes and benzoic, caffeic, cinnamic, and phenolic acids. It is also high in flavonoids, which may account for many of its health benefits. Turmeric (Curcumin) Curcumin, the active compound in turmeric, an orange-colored spice used for thousands of years in cooking and medicine, has been shown to have strong NFkB-modulating properties and plays a crucial role in balancing inflammation. Studies have also shown that curcumin supports the maintenance of remission from ongoing inflammation in the gastrointestinal tract, and promotes both gastrointestinal mucosal health and reduces stomach lining discomfort. Graminex® G60 Pollen Extract Graminex® G60 Pollen Extract is a high concentration, diverse array of phytochemicals with broad spectrum inflammatory balancing properties. They have been used successfully to maintain normal levels of inflammation. (1)

Sodium - 15mg
Pancreatin 8X USP - 350mg
Betaine Hydrochloride USP - 300mg
Pepsin 1:3,000 Powder - 150mg
Desiccated Ox Bile - 120mg
Bromelain (2,400 GDU/g) (from Pineapple) - 100mg
Papain (6,000 USP Units/mg) - 100mg (2)

The Bioflavonoid Advantage C-Flav is a formula that combines vitamin C with various bioflavonoids to mirror the way vitamin C is found in nature. Bioflavanoids are a group of plant pigments that provide the colors of many fruits and flowers. Bioflavonoid intake is associated with cardiovascular health and microbial balance.Created from multiple sources rich in vitamin C, C-Flav provides antioxidant protection, enhances immune function and provides support for healthy collagen synthesis and connective tissue. It also supports normal levels of inflammation throughout the body. (1)

Three Capsules Contain: Riboflavin (as Riboflavin 5'-Phosphate Sodium) 90 mg Vitamin B6 (as Pyridoxal 5'-Phosphate) 45 mg Folate (as L-5-Methyltetrahydrofolate from L-5-Methyltetrahydrofolic Acid, Glucosamine Salt) 3 mg Vitamin B12 (as Methylcobalamin) 3 mg Betaine Anhydrous (Trimethylglycine) 1.8 g Other Ingredients: Hypromellose (derived from cellulose) capsule, Calcium Citrate, Calcium Laurate. (1)

Three Capsules Contain: Vitamin A (3,000 IU from Beta Carotene and 2,000 IU as Palmitate) 5,000 IU. Vitamin C (as Ascorbic Acid) 150 mg. Vitamin D (as Vitamin D3) 1,000 IU. Vitamin E (as d-Alpha Tocopheryl) 50 IU. Vitamin K (as Vitamin K1) 100 mcg. Thiamin (as Thiamin HCl) 4 mg. Riboflavin (as Riboflavin 5'-Phosphate Sodium) 3.6 mg. Niacin (as Niacinamide) 30 mg. Vitamin B6 (as Pyridoxal 5'-Phosphate) 10 mg. Folate (500 mcg as Calcium Folinate and 500 mcg as L-5-Methyltetrahydrofolate from L-5-Methyltetrahydrofolic Acid, Glucosamine Salt) 1 mg. Vitamin B12 (100 mcg as Adenosylcobalamin and 100 mcg as Methylcobalamin) 200 mcg. Biotin 50 mcg. Pantothenic Acid (as Calcium Panothenate) 16 mg. Calcium (90 mg as Calcium Citrate and 90 mg as Calcium Malate) 180 mg. Iron (as Iron Picolinate) 45 mg. Iodine (as Potassium Iodide) 150 mcg. Magnesium (45 mg as Magnesium Citrate and 45 mg as Magnesium Malate) 90 mg. Zinc (as Zinc Picolinate) 25 mg. Selenium (as L-Selenomethionine) 50 mcg. Copper (as Copper Picolinate) 2 mg. Manganese (as Manganese Picolinate) 5 mg. Chromium (as TRAACS® Chromium Nicotinate Glycinate Chelate)* 100 mcg. Molybdenum (as Molybdenum Picolinate) 50 mcg. Boron (as Boron Picolinate) 1 mg. Lutein (from Aztec Marigold extract (flower) (Tagetes erecta)) 72 mcg. Other Ingredients: Hypromellose (derived from cellulose) capsule, Microcrystalline Cellulose, Calcium Laurate, Silicon Dioxide. *This product uses Albion’s TRAACS® Chromium Nicotinate Glycinate chelate. TRAACS is a registered trademark of Albion International, Inc. V16 (1)

Three Capsules Contain: Vitamin C (as Ascorbic Acid) 300 mg. Folate (as L-5-Methyltetrahydrofolate from L-5-Methyltetrahydrofolic Acid, Glucosamine Salt) 552 mcg. L-Arginine* 1 g. Green Tea Phytosome** (Camellia sinensis extract (leaf) / Phosphatidylcholine complex) 200 mg. R-Lipoic Acid (as Sodium R-Lipoic Acid)*** 50 mg. Trans-Resveratrol 50 mg. Other Ingredients: High and low viscosity hydroxypropyl methylcellulose and MagnesiumCitrateLaurate (Time-Sorb*), Hypromellose (derived from cellulose) capsule, Leucine, Silicon Dioxide. *L-Arginine complexed with Time-Sorb®, a time-release matrix. **This product uses Indena S.p.A.'s green tea phytosome (Greenselect®). Greenselect is a registered trademark of Indena S.p.A. ***This product uses GeroNova Research's Bio-Enhanced® R-Lipoic Acid. Bio-Enhanced is a registered trademark of GeroNova Research, Inc. Contains ingredient derived from soy (phytosome). (1)

Three Capsules Contains: Vitamin B12 (as Methylcobalamin) 1.5 mg. Folate (as L-5-Methyltetrahydrofolate from L-5-Methyltetrahydrofolic Acid, Glucosamine Salt ) 300 mcg. Acetyl-L-Carnitine (as Acetyl-L-Carnitine Chloride) 300 mg. Benfotiamine* 250 mg Coenzyme Q10 150 mg. Glutathione (Reduced) 150 mg. Phosphatidylserine 150 mg. R-Lipoic Acid (as Sodium R-Lipoic Acid)** 120 mg. *Benfotiamine is a source of Thiamin. Other Ingredients: Hypromellose (derived from cellulose) capsule, Microcrystalline Cellulose, MagnesiumCitrateLaurate, Leucine, Silicon Dioxide. **This product uses GeroNova Research's Bio-Enhanced® R-Lipoic Acid. Bio-Enhanced is a registered trademark of GeroNova Research, Inc. Contains ingredient derived from soy. (1)

Total Omega-3-s (as Triglycerides) - 950mg

EPA (Eicosapentaenoic Acid) - 430mg
DHA (Docosahexaenoic Acid) - 390mg
Omega-3s (additional) - 130mg (3)

Twelve Capsules Contain: Vitamin A (25,000 IU from Beta Carotene and 2,500 IU as Palmitate) 27,500 IU. Vitamin D (as Vitamin D3) 1,600 IU. Vitamin E (as d-Alpha Tocopheryl) 400 IU. Vitamin K (as Vitamin K1) 100 mcg. Vitamin C (as Calcium Ascorbate) 1 g. Thiamin (as Thiamin HCl) 200 mg. Riboflavin (as Riboflavin 5'-Phosphate Sodium) 50 mg. Niacin (100 mg as Niacinamide and 30 mg as Niacin) 130 mg. Vitamin B6 (as Pyridoxal 5'-Phosphate) 100 mg. Folate (500 mcg as Calcium Folinate and 500 mcg as L-5-Methyltetrahydrofolate from L-5-Methyltetrahydrofolic Acid, Glucosamine Salt) 1 mg. Vitamin B12 (225 mcg as Adenosylcobalamin and 225 mcg as Methylcobalamin) 450 mcg. Biotin 400 mcg. Pantothenic Acid (as Calcium Pantothenate) 400 mg. Calcium (60 mg as Calcium Ascorbate, 120 mg as Calcium Citrate, and 120 mg as Calcium Malate) 300 mg. Iodine (as Potassium Iodide) 150 mcg. Magnesium (240 mg as Magnesium Citrate and 240 mg as Magnesium Malate) 480 mg. Zinc (as Zinc Picolinate) 30 mg. Selenium (as L-Selenomethionine) 200 mcg. Manganese (as Manganese Picolinate) 6 mg. Chromium (as TRAACS® Chromium Nicotinate Glycinate Chelate)* 200 mcg. Molybdenum (as Molybdenum Picolinate) 100 mcg. Potassium (36 mg as Potassium Citrate and 36 mg as Potassium Malate) 72 mg. Choline Citrate 300 mg. N-Acetyl-L-Cysteine 200 mg. Methyl Sulfonyl Methane (MSM) 100 mg. Silybin Phytosome** (Silybum marianum extract (fruit) /Phosphatidylcholine complex) 100 mg. Curcumin Phytosome** (Curcuma longa extract (root) / Phosphatidylcholine complex) 100 mg. Inositol 60 mg. Green Tea Phytosome** (Camellia sinensis extract (leaf) / Phosphatidylcholine complex) 50 mg. R-Lipoic Acid (as Sodium R-Lipoic acid)**50 mg. Dandelion extract (root) (Taraxacum officinale) 10 mg. Boron (as Boron Picolinate) 3 mg. Lutein (from Aztec Marigold extract (flower) (Tagetes erecta) 288 mcg Vanadium (as Vanadium Picolinate) 100 mcg. Other Ingredients: Hypromellose (derived from cellulose) capsule, Microcrystalline Cellulose, Calcium Laurate, Silicon Dioxide. *This product uses Albion’s TRAACS® Chromium Nicotinate Glycinate chelate. TRAACS is a registered trademark of Albion Laboratories International, Inc. **This product uses GeroNova Research's Bio-Enhanced® R-Lipoic Acid and Indena S.p.A.'s silybin phytosome (Siliphos®), curcumin phytosome (Meriva®), and green tea phytosome (Greenselect®). Bio-Enhanced is a registered trademark of GeroNova Research, Inc. and Siliphos, Meriva, and Greenselect are registered trademarks of Indena S.p.A. Taraxacum PE 4:1. Contains ingredients derived from soy (phytosomes). (1)

Two Capsules Contain: Berberine HCl (from Indian Barberry extract) (root) (Berberis aristata) 1 g Other Ingredients: Hypromellose (derived from cellulose) capsule, Microcrystalline Cellulose, Silicon Dioxide, Leucine. Berberis Concentrate Berberine HCl 85%. (1)

Two Capsules Contain: Thiamin (as Thiamin HCl) 10 mg Riboflavin (as Riboflavin 5'-Phosphate Sodium) 10 mg Niacin (as Niacinamide) 10 mg Vitamin B6 (as Pyridoxal 5'-Phosphate) 10 mg Folate (as L-5-Methyltetrahydrofolate from L-5-Methyltetrahydrofolic Acid, Glucosamine Salt) 200 mcg Vitamin B12 (as Methylcobalamin) 100 mcg Proprietary Blend* 500 mg Magnolia officinalis (bark) extract Phellodendron amurense (bark) extract Other Ingredients: Hypromellose (derived from cellulose) capsule. *This product uses Relora® (a proprietary blend of a patented** extract from Magnolia officinalis bark and a proprietary extract from Phellodendron amurense bark). Relora® is a registered trademark of NPI, LLC. **Its use in this product is protected by U.S. Patent No. 6,582,735. (1)

Two Capsules Contain: Vitamin A (3,000 IU from Mixed Carotenes and 2,000 IU as Palmitate) 5,000 IU Vitamin C (as Ascorbic Acid) 250 mg Vitamin D (as Vitamin D3) 2,000 IU Vitamin E (as d-Alpha Tocopheryl Acid Succinate) 20 IU Vitamin K (200 mcg as Vitamin K1 and 200 mcg as Vitamin K2) 400 mcg Thiamin (as Thiamin HCl) 50 mg Riboflavin (as Riboflavin 5'-Phosphate Sodium) 12 mg Niacin (as Niacinamide) 80 mg Vitamin B6 (as Pyridoxal 5'-Phosphate) 20 mg Folate (as L-5-Methyltetrahydrofolate* from L-5-Methyltetrahydrofolic Acid, Glucosamine Salt) 400 mcg Vitamin B12 (as Methylcobalamin) 600 mcg Biotin 500 mcg Pantothenic Acid (as Calcium Pantothenate) 45 mg Calcium (as Calcium Bisglycinate Chelate) 30 mg Iodine (as Potassium Iodide) 75 mcg Magnesium (as Magnesium Bisglycinate Chelate) 20 mg Zinc (as Zinc Bisglycinate Chelate) 15 mg Selenium (as Selenomethionine) 200 mcg Copper (as Copper (II) Bisglycinate Chelate) 750 mcg Manganese (as Manganese (II) Bisglycinate Chelate) 3 mg Chromium (as Chromium Nicotinate Glycinate Chelate) 400 mcg Molybdenum (as Molybdenum (II) Glycinate Chelate) 100 mcg d-Gamma Tocopherol (from Mixed Tocopherols) 24 mg Boron (as Bororganic Glycine) 2 mg Other Ingredients: Hypromellose (derived from cellulose) capsule, Microcrystalline Cellulose, Calcium Laurate, Silicon Dioxide. Gamma tocopherol does not have a recognized IU equivalent. *This product uses Gnosis S.p.A.'s L-5-Methyltetrahydrofolic Acid, Glucosamine Salt (Quatrefolic®). Quatrefolic is a registered trademark of Gnosis S.p.A. (1)

Two Capsules Contain: Vitamin C (as Ascorbic Acid) 250 mg Vitamin B6 (as Pyridoxal 5'-Phosphate) 5 mg Folate (as L-5-Methyltetrahydrofolate from L-5-Methyltetrahydrofolic Acid, Glucosamine Salt)* 400 mcg Vitamin B12 (as Methylcobalamin) 550 mcg Pantothenic Acid (as Calcium Pantothenate) 130 mg Iodine (as Potassium Iodide) 68 mcg L-Tyrosine 200 mg 5-Hydroxytryptophan 50 mg Eleuthero extract (root) (Eleutherococcus senticosus) 50 mg Gamma-Aminobutyric Acid (GABA)** 50 mg Rhodiola extract (root) (Rhodiola rosea) 50 mg Other Ingredients: Hypromellose (derived from cellulose) capsule, Leucine, MagnesiumCitrateLaurate, Silicon Dioxide. *This product uses Gnosis S.p.A.'s L-5-Methyltetrahydrofolic Acid, Glucosamine Salt (Quatrefolic®). Quatrefolic is a registered trademark of Gnosis S.p.A. **This product uses Pharma Foods International's Gamma-Aminobutyric Acid (PharmaGABA®). PharmaGABA is a registered trademark of Pharma Foods International. Eleutherococcus standardized to Eleutherosides 0.5%. Rhodiola standardized to Total Rosavins 3%. (1)

Two Capsules Contain:

Curcumin Phytosome† (Curcuma longa extract (root) / Phospholipid complex from Sunflower) 500 mg

Other Ingredients: High and low viscosity hydroxypropyl methylcellulose, Calcium Citrate, and Calcium Laurate (Time-Sorb††), Hypromellose (derived from cellulose) capsule, Leucine, Silicon Dioxide, Microcrystalline Cellulose.

†This product uses Indena S.p.A.'s curcumin phytosome (Meriva®). Meriva is a registered trademark of Indena S.p.A.

††Curcumin Phytosome (Meriva®) complexed with Time-Sorb®, a time-release matrix. (1)

Two Drops Contain: Vitamin D (as Vitamin D3) 1,000 IU. Other Ingredients: Medium Chain Triglyceride Oil, Mixed Tocopherols. (1)

Two Drops Contain: Vitamin D (as Vitamin D3) 1,000 IU. Vitamin K (as Vitamin K2 (Menatetrenone))* 200 mcg. *MK4 Other Ingredients: Medium Chain Triglyceride Oil, Mixed Tocopherols. (1)

Two Gel Caps Contain:

Calories 20
Total Fat 2 g
EPA (Eicosapentaenoic Acid Ethyl Ester) (from Fish Oil*) 1,300 mg
DHA (Docosahexaenoic Acid Ethyl Ester) (from Fish Oil*) 200 mg

Other Ingredients: Gelatin (bovine), Purified Water and Glycerin (vegetable source) gel cap, Vitamin E (mixed tocopherols).

*This product uses Supercritical CO2 extracted and chromatographed fish oil derived solely from anchovies.

Contains ingredients derived from fish (fish oil = anchovy). (1)

Two Gelcaps Contain: Calories 20 Calories from Fat 20 Total Fat 2 g. Saturated Fat 0 g. Trans Fat 0 g. EPA (Eicosapentaenoic Acid Ethyl Ester) (from Fish Oil*) 1,300 mg. DHA (Docosahexaenoic Acid Ethyl Ester) (from Fish Oil*) 200 mg. Other Ingredients: Gelatin (bovine), Purified Water and Glycerin (vegetable source) gelcap, Vitamin E (mixed tocopherols). *This product uses Supercritical CO2 extracted and chromatographed fish oil derived solely from anchovies. Contains ingredients derived from fish (fish oil = anchovy). (1)

Two Tablets Contain:

SR CarnoSyn® Beta-alanine† 1.6 g

Other Ingredients: Hypromellose, Dicalcium Phosphate, Corn Starch, Rice Extract, Hydroxypropyl Cellulose, Silicon Dioxide.

†This product uses CarnoSyn® Beta Alanine. Natural Alternatives International (NAI) is the owner of patents as listed on www.carnosyn.com and registered trademarks CarnoSyn® and SR CarnoSyn®. (1)

Ultra Potent-C® [calcium ascorbate, niacinamide ascorbate, ascorbic acid, xylitol, sodium ascorbate, magnesium ascorbate, L-lysine HCl, ascorbyl palmitate, citrus bioflavonoid complex, potassium ascorbate, tetrasodium pyrophosphate, alpha D-ribofuranose, L-cysteine HCI, and L-glutathione], proprietary mushroom decoction, microcrystalline cellulose, oleanolic acid, cellulose, calcium silicate, stearic acid (vegetable), croscarmellose sodium, silica, zinc citrate, selenomethionine, magnesium stearate (vegetable), cholecalciferol, and coating (hypromellose, medium chain triglycerides, and hydroxypropylcellulose). (1)

Vitamin B12 Because of its role in the production of cellular energy, vitamin B12 deficiency is often characterized by fatigue and weakness. Supplementation with methylcobalamin and 5-MTHF has been shown to promote increased energy levels. Both 5-MTHF and methylcobalamin are required to maintain optimal homocysteine balance, which is crucial for supporting arterial and cardiovascular health. In addition, 5-MTHF and methylcobalamin support healthy arterial blood flow by increasing nitric oxide production. Both are also required nutrients for the biosynthesis of melatonin-the hormone that helps induce sleep. Several studies have demonstrated that supplementation with methylcobalamin modulates melatonin secretion and helps to normalize the sleep-wake cycle. Vitamin B12 has been shown to be beneficial for maintaining a positive mental outlook because it acts as a methyl donor and increases the synthesis of SAM-e, a nutrient that has powerful mood and sleep-cycle regulating properties. Because of its ability to increase the production of neurotransmitters and nerve cell transmission, B12 has also been shown to improve cognitive function. (1)

Vitamin D Vitamin D is most widely known as the sunshine vitamin because the body is able to make vitamin D when exposed to sunlight. Vitamin D plays an important role in supporting bone health, maintaining cardiovascular function and immune function, and promoting an overall sense of well-being. Vitamin D is available in two different forms, D2 and D3. Vitamin D3 is the preferable form as it has been found to maintain vitamin D levels in the body for a longer period of time when compared to vitamin D2. Vitamin K Vitamin K is a family of similarly structured molecules. There are three different vitamin K molecules. Vitamin K2 (menaquinones) is produced naturally by bacteria, unlike its more popular cousin, vitamin K1, which is found in greater concentrations in green leafy vegetables. The combination of vitamin K2 with vitamin D3 has been suggested in recent studies to promote bone health. (1)

Vitamin E Vitamin E is one of the most scientifically sound regimens for the body’s fight against the free radicals that damage cells and influence the aging process. There are four different forms of vitamin E tocopherols: alpha, beta, gamma and delta. Each provide antioxidant activity and are naturally sourced in this formula. Through its antioxidant activity, vitamin E has been shown to support cardiovascular, neurological, ocular and immune health. (1)

Vitamin K Calcium and vitamin D are important mediators in bone growth, but vitamin K plays an equally important role. The synthesis of bone growth is dependent on vitamin K, through its carboxylation of osteocalcin, a protein secreted by osteoblasts. Osteocalcin guides calcium into bones and prevents its absorption into organs, joint spaces and arteries. Vitamin K occurs in three main forms: K1 (phylloquinone), found primarily in the liver, naturally occurs in green leafy vegetables and is considered to be the main dietary source; K2 (menaquinone), which is a group name for a family of related compounds differentiated by their side chains; and K3 (menadione), which does not have vitamin K activity. MK-4 and MK-7 are the two subclasses of K2 most widely studied for their role in bone and cardiovascular health. MK-4 is primarily a metabolic byproduct of K1 while MK-7 is found in small quantities in liver mitochondria and other tissues.The MK-7 form is substantially more active, has a longer half-life and accumulates to higher concentrations in serum than vitamin K1. The different degrees of bioavailability between K1 and K2 are due to differences in structure. The long side-chain of vitamin K2 (specifically MK-7) allows it to bind with fat particles in circulation. This process then allows easier facilitation to soft tissue, bones and arteries. More recently, research has shown that doses of 180 mcg of MK-7 provide greater results when supporting both bone and cardiovascular health. (1)

Vitamin K2/D3 Vitamin K is a family of similarly structured molecules. There are three different vitamin K molecules. Vitamin K2, menaquinones, are produced naturally by bacteria unlike its more popular cousin, vitamin K1, which is found in greater concentrations in green leafy vegetables. The combination of vitamin K2 with vitamin D3 has been suggested in recent studies to promote bone health. (1)

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